Deborah Twiss
- Birthday: 1971-12-22
- Place of birth: Philadelphia, Pennsylvania, USA
Deborah Twiss (born December 22, 1971) is an American actress, screenwriter, film director and producer. In the 2000s she became well-known with roles in films and television shows such as Kick-Ass, Gravity, Law & Order: Special Victims Unit and White Collar.
