Khesya Lokshina
- Birthday: 1902-12-17
- Deathday: 1982-06-01
- Place of birth: Roslavl, Smolensk province, Russian empire
- Also know as: Х. Локшина
Khesya Aleksandrovna Lokshina was a Soviet film and theatre director and screenwriter. She co-directed a number of films with her husband Erast Garin, a renowned Soviet actor and director.
