Cattlemen's Protective Association agent Tom Wade and his partner Happy are assigned to look into the disappearance of rancher John Carroll, who has been abducted by Carson, who wants to use his out-of-the-way ranch as a base for his smuggling operations. Complications arise as Carrol's daughter, Rita, looking for him, has an unfriendly run-in with Wade, then later is herself kidnapped by Carson.
Ray, young and destitute, reaches Desert Spring, carrying a case on top of his mule. A gang headed by Brady uses apparently legal means to prevent anyone from trading and exploits all the town's possibilities for itself. The only one who dares to protest is Sheila, the daughter of a tradesman who has been ruined by Brady. She therefore welcomes Ray, hoping to make him an ally. But the young man doesn't even known how to handle a gun. However, when Brady's men beat him up and humiliate him, Ray decides to stay.
Hoppy, California and Johnny partner up with brother and sister ranch owners, two of several who are having their access to water blocked by a dam owned by a greedy merchant in town, who is intent on driving them out and taking their land for himself.
Eight years ago, Cheyenne Indians attacked the Baudine Family wagon and captured Morgan, whom they renamed Two Persons. Now Two Persons, raised in the ways of the Indians, has been reunited with his brother Quentin, a doctor and a stranger to frontier ways. Together the brothers set out in search of their sister Patricia, who was also captured and who Two Persons believes is still alive.
The small desert town of Black City is held in a reign of terror by a nasty gang of criminals lead by the ruthless Bud Willer. Earnest, but inexperienced Sheriff Jack Ronson arrives in town to establish law and order. Mysterious bounty hunter Django helps Ronson out.
Skipalong Rosenbloom is the star of a heavily commercialized TV kiddie show, presided over by a smarmy announcer. He is at odds with western bad guy Butcher Baer.
Prospector Jeff Malloy rescues Doris Devlin, owner of a trading post, from an ambush planned by her uncle, Kilburn, who is trying to scare her out of the territory so that he can continue his counterfeiting operations.
On vacation at his ranch, western actor Roy quickly finds himself involved with a horse rustling operation and a boy ward of one of the rustlers, leading to the kidnapping of Roy's trick horse Trigger by the gang with a demand for ransom.
Sando Kid is a medic on the battlefields of the civil war and a pacifist. One day he witnesses Yankee captain Grayton ruthlessly killing wounded and unarmed soldiers. He manages to survive thanks to the help of a friend and learns how to use a gun. From now on, he will sign up to the rangers and hunt down bandits. He soon crosses paths with Grayton again, who now has become a ruthless business man, trying to rob farmers of their land. Together with his henchmen, Grayton might be more than Sando Kid can handle, if it wasn't for Dollar, a black-clad bounty hunter who likes to wear a chain of teeth around his neck, and really likes the Kid.
Captain Maddocks will never be promoted beyond Captain because of a mistake that he made in the past. Lt. McQuade is a green rookie who is now under the command of the tough Captain and he does not seem to be able to do anything right. Lt. McQuade also has trouble with Tracey, but it will be the renegade Indians that will test him and teach him the importance of following orders.
Tom Destry, son of a legendary frontier peacekeeper, doesn’t believe in gunplay. Thus he becomes the object of widespread ridicule when he rides into the wide-open town of Bottleneck, the personal fiefdom of the crooked Kent.
A scruffy garbage boy becomes the pupil of famed gunfighter Talby, and the stage for confrontation is set when the gunman overruns the boy's town through violence and corruption.