Trinity series star Bud Spencer returns to the Wild West in director Michele Lupo's comic tale of an outlaw drifter, Buddy, who is mistaken for a doctor after his Indian companion inadvertently steals a bag of surgical instruments. When a band of murderous outlaws attempts to overrun the small town Buddy is passing through, the presumed medico shows that his true talent is cracking skulls. Music is composed by Ennio Morricone.
Summoned to Shadow Ranch by his friend Ranny Williams, Sim Baldwin arrives to find Ranny has been ambushed and murdered. Sim learns ranch owner Ruth Cameron is under pressure to sell out to Dan Blake, as the dam on the ranch controls the town's water supply. Vowing to avenge his old friend's death, Sim takes up Ruth's fight and incurs Blake's hostility.
Richard Dix as Dan Taylor and Preston S. Foster as Paxton Bryce are two longtime friends seeking their fortune in Texas after the war. The two men decide, not without problems, to establish a cattle empire. Paxton becoming too ambitious, distances himself from Dan and Abby, Paxton's wife. It will only be after a personal tragedy that he will come back to his senses.
Evil Grant Withers lets a killer horse loose to ruin valuable horses on nearby ranches. He hopes to shake down the ranchers for his "protection". Roy tracks down the bad guys, but is suddenly trapped by them. Peter Miles, a boy terrified of horses, overcomes his fear and rides for help to save the day.
After a gang of violent outlaws forces a Native American woman to lead them through a treacherous forest in search of a fortune in gold, they unknowingly awaken an ancient, bloodthirsty beast that will stop at nothing to annihilate them all.
Jack Beauregard, an aging gunman of the Old West, only wants to retire in peace and move to Europe, but a young gunfighter known as "Nobody" who idolizes Beauregard wants him to go out in a blaze of glory. So, he arranges for Jack to face the 150-man gang known as The Wild Bunch and earn his place in history.
In 1897, veteran bounty hunter Max Borlund is deep into Mexico where he encounters professional gambler and outlaw Joe Cribbens — a sworn enemy he sent to prison years before. Max is on a mission to find and return Rachel Kidd, the wife of a wealthy businessman, who as the story is told to Max, has been abducted by Buffalo Soldier Elijah Jones. Max is ultimately faced with a showdown to save honor.
In a near future, a woman hitchhikes alone in the desert towards the promise of a Utopian dome on the horizon. When she negotiates a ride with strangers, we learn to trust no one on the road to the Neo-Dome.
When Len Stoddard wins Ted Ames ranch in a poker game he sends his brother Jake along with Ted to take over the ranch. When Jake is found murdered he offers a reward for the capture of Ted who now is believed to be a member of the Black Aces gang. Ted finds the probable location of the gang's hideout and sets out to clear himself.
Don Juan, the governor of a Mexican province, arrests Manuel, the fiancé of the beautiful heiress, Virginia. When Quintana frees Manuel, Don Juan kidnaps Virginia to force her hand in marriage. The ceremony is interrupted in a violent battle.